Description
Triple negative breast cancer (TNBC) is a type of breast cancer that lacks the three most common hormone receptors: growth factor receptor 2 (HER-2), estrogen receptors (ER), and progesterone receptors (PR). Most of the common breast cancer treatments target these receptors. Therefore, individuals with triple negative breast cancer do not have access to these therapies. However, chemotherapy works well for TNBC and may be given before or after surgery. TNBC tends to grow quickly and has a worse outcome than other types of breast cancer.
Symptoms
Symptoms may include a breast lump, change in breast skin texture, change in size of the breast or nipple discharge.
Tests
Common tests used for diagnosis and treatment
Workup:
A history and physical exam will be performed. Testing usually includes a mammogram. Ultrasound of the breast may also be performed. Diagnosis is confirmed with a biopsy or during surgery. A CT or PET scan may be performed to see if the cancer has spread beyond the breast.
Tests:
Biopsy, Mammogram, Ultrasound
Other Specific Tests: Genetic testing, MRI, CT scan
Specialists:
General Surgery, Obstetrics and Gynecology, Blood and Cancer Care (hematology and oncology), Surgical Oncology
Workup:
A history and physical exam will be performed. Testing usually includes a mammogram. Ultrasound of the breast may also be performed. Diagnosis is confirmed with a biopsy or during surgery. A CT or PET scan may be performed to see if the cancer has spread beyond the breast.
Tests:
Biopsy, Mammogram, Ultrasound
Other Specific Tests: Genetic testing, MRI, CT scan
Specialists:
General Surgery, Obstetrics and Gynecology, Blood and Cancer Care (hematology and oncology), Surgical Oncology
Treatment
Treatment depends on the extent of the disease. A combination of surgery and chemotherapy with or without radiation therapy will likely be used.